HOW TYSABRI MAY WORK

Explore a monoclonal antibody that may help control inflammatory activity in relapsing MS through inhibition of α4-integrin1

The specific mechanism(s) by which TYSABRI exerts its effects in relapsing MS have not been fully defined.

In demyelinating diseases such as MS, evidence suggests α4-integrin may play a key role in inhibiting CNS migration of lymphocytes—a trigger in the inflammatory process in MS1,2

TYSABRI is a monoclonal antibody that binds to α4-integrin—a known target in the pathogenesis of MS

  • The α4 subunit α4β1 integrin is expressed on the surface of all leukocytes (except neutrophils)

TYSABRI may exert its effects by blocking the interaction of α4-integrin with adhesion molecules on the vascular endothelium

This may prevent the migration of leukocytes across the blood-brain barrier, inhibiting further recruitment and inflammatory activity of activated immune cells

TYSABRI may further act to inhibit the interaction of α4-expressing leukocytes with their ligands in the extracellular matrix and on parenchymal cells, thereby inhibiting further recruitment and inflammatory activity of activated immune cells

CNS=central nervous system.