POOR PROGNOSIS MAY REQUIRE DECISIVE ACTION

  • MS is the most common inflammatory neurologic disease in young adults1
  • Cumulative effects of disease activity incurred early in the disease course may lead to progressive disease and long-term neurologic damage2

THERE IS A SIGNIFICANT CORRELATION BETWEEN INCREASE IN T2 LESION VOLUME AND DISABILITY WORSENING OVER THE FIRST 5 YEARS3

Adapted from Comi, Clin Ther, 2009; Compston, Lancet, 2008; Fisniku, Brain, 2008; and Trapp, Neuroscientist, 1999.3-6
For illustrative purposes only.

MRI can help detect subclinical disease7,8

  • Asymptomatic brain and spinal cord lesions can predict relapses9
  • 58% of new spinal cord lesions are asymptomatic9

Inadequate response to treatment can be identified with monitoring10

An inadequate response can be defined by a combination of parameters, which may include:

MRI Activity
  • New/enlarged T2 lesions or Gd+ lesions10
Level of Disability
  • Increase in EDSS score10
Relapse Frequency
  • Incidence of relapse while on treatment10